Oxidative activation of O,S-dimethyl phosphoramidothiolate

O,S-Dimethyl phosphoramidothiolate, the insecticide methamidophos, is converted oxidatively into a potent anti-cholinesterase agent by the action of m-chloroperbenzoic acid. The active intermediate is not stable enough to be isolated. From some chemical evidence, the sulfoxide, i.e., dimethyl phosph...

Full description

Saved in:
Bibliographic Details
Published inPesticide biochemistry and physiology Vol. 7; no. 4; pp. 367 - 377
Main Authors Eto, Morifusa, Okabe, Sachiko, Ozoe, Yoshihisa, Maekawa, Kazuyuki
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.01.1977
Online AccessGet full text

Cover

More Information
Summary:O,S-Dimethyl phosphoramidothiolate, the insecticide methamidophos, is converted oxidatively into a potent anti-cholinesterase agent by the action of m-chloroperbenzoic acid. The active intermediate is not stable enough to be isolated. From some chemical evidence, the sulfoxide, i.e., dimethyl phosphoramidothiolate S-oxide, is most probably the active intermediate. A similar activation may occur by biological oxidation.
ISSN:0048-3575
1095-9939
DOI:10.1016/0048-3575(77)90041-4