An improved procedure to homochiral cyclic statines

Chiral tetramic acids were prepared in high yields by the reaction of N-protected amino acids with Meldrum's acid employing DCC as a carboxyl activating agent. Reduction or hydrogenation of these tetramic acids produced homochiral cyclic statines. Graphic

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 7; no. 8; pp. 2365 - 2370
Main Authors Ma, DW, Ma, JY, Ding, WL, Dai, LX
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.08.1996
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
TETRAMIC ACIDS
(3S,4S)-STATINE
ANALOGS
DERIVATIVES
L-657,398
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Summary:Chiral tetramic acids were prepared in high yields by the reaction of N-protected amino acids with Meldrum's acid employing DCC as a carboxyl activating agent. Reduction or hydrogenation of these tetramic acids produced homochiral cyclic statines. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/0957-4166(96)00291-1