A novel bromopyrrole alkaloid from the sponge Agelas longissima with antiserotonergic activity

Agelongine ( 1), a novel bromopyrrole alkaloid containing a pyridinium ring in place of the imidazole nucleus, usually found in Agelas alkaloids, has been isolated from the Caribbean sponge Agelas longissima, and its structure established by spectroscopic analysis and chemical degradation. Agelongin...

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Published inBioorganic & medicinal chemistry letters Vol. 5; no. 8; pp. 799 - 804
Main Authors Cafieri, Francesco, Fattorusso, Ernesto, Mangoni, Alfonso, Taglialatela-Scafati, Orazio, Carnuccio, Rosa
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 20.04.1995
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Summary:Agelongine ( 1), a novel bromopyrrole alkaloid containing a pyridinium ring in place of the imidazole nucleus, usually found in Agelas alkaloids, has been isolated from the Caribbean sponge Agelas longissima, and its structure established by spectroscopic analysis and chemical degradation. Agelongine exhibited an antiserotonergic activity tested in vitro on the rat stomach fundus strip. Agelongine ( 1), a novel bromopyrrole alkaloid containing an unusual pyridinium ring, has been isolated from the Caribbean sponge Agelas longissima. Agelongine exhibited an antiserotonergic activity tested in vitro on the rat stomach fundus strip.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00116-B