Synthesis of enantiopure amino alcohols by ring-opening of epoxyalcohols and epoxyethers with ammonia

Arylglycidols and their corresponding ethers undergo regioselective ring-opening with aqueous ammonia in the presence of organic co-solvents (isopropanol or 1,4-dioxane) to afford 1,2-amino alcohols in high yield. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 44; no. 46; pp. 8369 - 8372
Main Authors Pastó, Mireia, Rodrı́guez, Belén, Riera, Antoni, Pericàs, Miquel A.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 10.11.2003
Elsevier
Subjects
amino alcohols
ammonia
Chemistry
Chemistry, Organic
epoxides
Physical Sciences
ring-opening
Science & Technology
ammonia
ring-opening
epoxides
amino alcohols
CHIRAL LIGANDS
ENANTIOSELECTIVE SYNTHESIS
VERSATILE
ACIDS
FAMILY
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Summary:Arylglycidols and their corresponding ethers undergo regioselective ring-opening with aqueous ammonia in the presence of organic co-solvents (isopropanol or 1,4-dioxane) to afford 1,2-amino alcohols in high yield. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2003.09.124