Synthesis of enantiopure amino alcohols by ring-opening of epoxyalcohols and epoxyethers with ammonia
Arylglycidols and their corresponding ethers undergo regioselective ring-opening with aqueous ammonia in the presence of organic co-solvents (isopropanol or 1,4-dioxane) to afford 1,2-amino alcohols in high yield. Graphic
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Published in | Tetrahedron letters Vol. 44; no. 46; pp. 8369 - 8372 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
10.11.2003
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Arylglycidols and their corresponding ethers undergo regioselective ring-opening with aqueous ammonia in the presence of organic co-solvents (isopropanol or 1,4-dioxane) to afford 1,2-amino alcohols in high yield.
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2003.09.124 |