(±)-Involucrasin D, a pair of enantiomeric bisflavonoid from the roots of Shuteria involucrata and its anti-inflammatory activity

An undescribed bisflavonoid, named involucrasin D ( ), along with two known flavonoids, 2(S)7,3',5'-trihydroxydihydroflavone ( ) and sigmone ( ) were isolated from the roots of . A further chiral separation of to yielded a pair of enantiomers (+)- and (-)- . The structures were elucidated...

Full description

Saved in:
Bibliographic Details
Published inNatural product research pp. 1 - 9
Main Authors Zhou, Xiaoying, Jin, Qiong, Zhang, Bingruo, Wei, Lisha, Bao, Lue, Jiang, Xiaoyun, Duan, Rong, Liu, Lu, Yang, Zhuya
Format Journal Article
LanguageEnglish
Published England 08.04.2024
Subjects
involucrasin D
enantiomeric bisflavonoid
Shuteria involucrata
anti-inflammatory activity
Online AccessGet full text

Cover

More Information
Summary:An undescribed bisflavonoid, named involucrasin D ( ), along with two known flavonoids, 2(S)7,3',5'-trihydroxydihydroflavone ( ) and sigmone ( ) were isolated from the roots of . A further chiral separation of to yielded a pair of enantiomers (+)- and (-)- . The structures were elucidated based on spectroscopic analyses and electron circular dichroism (ECD) calculations. Among them, bisflavonoid and its enantiomers displayed remarkable anti-inflammatory effects by inhibiting the production of TNF- and IL-6 in a dose-dependent manner.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2024.2332486