Epidemiology and early screening strategies for colorectal cancer in China

China ranks the first worldwide in the number of new colorectal cancer (CRC) cases and CRC-related deaths. The increasing incidence of early-onset CRC in recent years highlights the challenges related to CRC screening and prevention. High-quality colonoscopy is the universally used gold standard for...

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Published inChinese journal of cancer research Vol. 35; no. 6; pp. 606 - 617
Main Authors Yang, Yong, Gao, Zhaoya, Huang, An, Shi, Jingyi, Sun, Zhuang, Hong, Haopeng, Gu, Jin
Format Journal Article
LanguageEnglish
Published China AME Publishing Company 30.12.2023
Subjects
Review
epidemiology
early screening
review
Colorectal cancer
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Summary:China ranks the first worldwide in the number of new colorectal cancer (CRC) cases and CRC-related deaths. The increasing incidence of early-onset CRC in recent years highlights the challenges related to CRC screening and prevention. High-quality colonoscopy is the universally used gold standard for CRC screening. Risk assessment combined with a two-step screening strategy based on colonoscopy and non-invasive examinations was proven to be highly effective. However, systematic use of well-established risk factors associated with CRC, beyond age, could better identify those who might harbor advanced colorectal neoplasia, improve the diagnostic yield of current screening modalities, and optimize the selection of individuals who might benefit most from preventive strategies. "Personalization" and "Standardization" are the future development directions of CRC screening, from the initiation of screening in those at high risk for CRC to follow-up after treatment, which are the key to ensure the screening efficiency.
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ISSN:1000-9604
1993-0631
DOI:10.21147/j.issn.1000-9604.2023.06.05