Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking

In this work, a series of piperazine substituted indole derivatives were synthesized and evaluated for their in vitro antioxidant and anti-inflammatory activities. The results of antioxidant activity showed that compounds 2 (81.63%) and 11 (85.63%) had comparable DPPH free radical scavenging activit...

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Published inJournal of Research in Pharmacy Vol. 24; no. 3; pp. 350 - 360
Main Authors BAYDAR, Aziz, KILIÇ-KURT, Zühal, ACAR, Cemre, YILMAZ-SARIALTIN, Sezen, ALTUNTAŞ, Tunca Gül
Format Journal Article
LanguageEnglish
Published Istanbul Marmara University 01.01.2020
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Summary:In this work, a series of piperazine substituted indole derivatives were synthesized and evaluated for their in vitro antioxidant and anti-inflammatory activities. The results of antioxidant activity showed that compounds 2 (81.63%) and 11 (85.63%) had comparable DPPH free radical scavenging activity to Vit E (88.6%). The in vitro anti-inflammatory assays indicated that most of the compounds had more higher anti-inflammatory activities than standart ASA. Docking results revealed that compound 11 possessing the strongest anti-inflammatory activities showed the H-bond interactions with the key residues of COX-2 active site. It suggested that the anti-inflammatory activity of the compounds might result from COX-2 inhibition. It will be verified with further enzyme inhibition assays.
ISSN:2630-6344
2630-6344
DOI:10.35333/jrp.2020.157