The mitochondrial processing peptidase

The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is...

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Published inThe international journal of biochemistry & cell biology Vol. 29; no. 8-9; pp. 1043 - 1045
Main Authors Braun, H P, Schmitz, U K
Format Journal Article
LanguageEnglish
Published Netherlands 01.08.1997
Subjects
Animals
Biological Transport
Dimerization
Metalloendopeptidases - biosynthesis
Metalloendopeptidases - chemistry
Metalloendopeptidases - metabolism
Metalloendopeptidases - physiology
Mitochondria - metabolism
Mitochondrial Processing Peptidase
Neurospora - enzymology
Plants - enzymology
Protein Sorting Signals - metabolism
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Summary:The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1357-2725
DOI:10.1016/S1357-2725(97)00032-0