Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase

• Published in: Bioorganic & medicinal chemistry letters Vol. 6; no. 6; pp. 625 - 630
• Main Authors: Fink, David M., Palermo, M.G., Bores, Gina M., Huger, Francis P., Kurys, Barbara E., Merriman, Michael C., Olsen, Gordon E., Petko, Wayne, O'Malley, Gerard J.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 19.03.1996
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/0960-894X(96)00072-8

A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A. A series of imino 1,2,3,4-tetrahydrocyclopen[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A.