Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase

A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affin...

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Published inBioorganic & medicinal chemistry letters Vol. 6; no. 6; pp. 625 - 630
Main Authors Fink, David M., Palermo, M.G., Bores, Gina M., Huger, Francis P., Kurys, Barbara E., Merriman, Michael C., Olsen, Gordon E., Petko, Wayne, O'Malley, Gerard J.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 19.03.1996
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Summary:A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A. A series of imino 1,2,3,4-tetrahydrocyclopen[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00072-8