A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5( Z),8( Z),11( Z),14( Z)-tetraenoic acids (18-, 19-, and 20-HETEs)

Suzuki–Miyaura cross-coupling of cis-vinylbromide 6 with functionalized boranes provides a practical, stereospecific route to the title CYP P450 eicosanoids. Suzuki–Miyaura cross-coupling of cis-vinylbromide 6 , obtained in three steps from diol 4 , with functionalized boranes provides a practical,...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 12; pp. 2563 - 2565
Main Authors Gopal, V.Raj, Jagadeesh, S.G., Reddy, Y.Krishna, Bandyopadhyay, A., Capdevila, Jorge H., Falck, J.R.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.03.2004
Elsevier
Subjects
Biologically active compounds
Chemistry
Chemistry, Organic
Eicosanoids
Lipids
Physical Sciences
Science & Technology
Suzuki reactions
Biologically active compounds
Eicosanoids
Lipids
Suzuki reactions
eicosanoids
lipids
METABOLITES
TRANSPORT
DAHL SS/JR RATS
ARACHIDONIC-ACID
biologically active compounds
CYTOCHROME-P-450
18-HYDROXYEICOSATETRAENOIC ACIDS
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Summary:Suzuki–Miyaura cross-coupling of cis-vinylbromide 6 with functionalized boranes provides a practical, stereospecific route to the title CYP P450 eicosanoids. Suzuki–Miyaura cross-coupling of cis-vinylbromide 6 , obtained in three steps from diol 4 , with functionalized boranes provides a practical, stereospecific route to the title CYP P450 eicosanoids.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.01.151