Low IGFBP-1 is a marker of impaired skin vascular response to both endothelial and non-endothelial stimulation in healthy males

• Published in: Diabetes & metabolic syndrome clinical research & reviews Vol. 3; no. 2; pp. 103 - 108
• Main Authors: Lehtihet, Mikael, Jörneskog, Gun, Alvarsson, Michael, Båvenholm, Peter, Katz, Abram, Efendic, Suad, Östenson, Claes-Göran, Kuhl, Jeanette, Brismar, Kerstin
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2009
• Subjects: Acetylcholine; Diabetes heredity; Doppler fluxmetry; Endocrinology & Metabolism; Flow-mediated vasodilation; IGF-1; IGFBP-1; Laser Doppler perfusion imaging; Skin microcirculation; Sodium nitroprusside; Videophotometric capillaroscopy; insulin-like growth factor binding protein-1; NO; oral glucose tolerance test; Flow-mediated vasodilation; insulin-like growth factor-1; LDF; Skin microcirculation; IGFBP-1; SNP; sodium nitroprusside; CBV; FMD; Videophotometric capillaroscopy; Diabetes heredity; Vascular smooth muscle cells; BMI; nitric oxide; body mass index; Ach; flow-mediated vasodilatation; nitroglycerine; IGF-1; laser Doppler flux; Doppler fluxmetry; capillary blood cell velocity; Laser Doppler perfusion imaging; NGT; acetylcholine; VSMC; vascular smooth muscle cell; OGTT; Sodium nitroprusside; Acetylcholine
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2009.04.009

Abstract Vascular endothelial dysfunction is an early event in the development of atherosclerosis and is also linked to insulin resistance and type 2 diabetes mellitus. Serum IGFBP-1 and IGF can be used as markers of insulin sensitivity and secretion. The aim was to investigate if microvascular reactivity in healthy males with and without heredity of type 2 diabetes mellitus is related to serum levels of IGF-1 and its binding protein IGFBP-1. Thirty-six middle-aged male subjects free of medication, non-smokers and with normal oral glucose tolerance test were investigated. Nineteen of the subjects had known heredity for type 2 diabetes. The groups were matched for age and body mass index. Skin microcirculation was studied with laser Doppler perfusion imaging before and after iontophoretic application of endothelial (acetylcholine (Ach)) and non-endothelial dependent (sodium nitroprusside (SNP)) substances. The microvascular responses to iontophoretic application of Ach and SNP, respectively, were weaker ( p = 0.01 and p = 0.02, respectively) in subjects with diabetes heredity than in those without. In subjects without heredity a significant correlation was observed between the peak microvascular responses to Ach ( r = 0.57; p < 0.02), SNP ( r = 0.51; p < 0.05), and levels of IGFBP-1, while no significant correlation was found in subjects with diabetes heredity. In summary our study shows that healthy male subjects with no heredity for type 2 diabetes have low fasting IGFBP-1 which were associated with impaired microvascular responses to both endothelial and non-endothelial stimulation.