Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine

Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor benzyl farnesyl amine. Graphic

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 6; no. 21; pp. 2491 - 2494
Main Authors Brinkman, John A., Damon, Robert E., Fell, Jay B., Perez, Lawerence B., Scallen, Terence J., Vedamanda, T.R.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 05.11.1996
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Summary:Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor benzyl farnesyl amine. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00470-2