The use of three baseline values in intervention studies: application to evaluation of immune modulation therapies

In studying the effects of a treatment intervention on immunological parameters, we have found that three baseline values are a practical number to obtain on each patient. Three baseline values 1) increase the chances of detecting a statistically significant effect of the intervention, 2) provide an...

Full description

Saved in:
Bibliographic Details
Published inImmunobiology (1979) Vol. 167; no. 5; p. 431
Main Authors Korn, E L, Dorey, F, Spina, C A, Fahey, J L
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.1984
Subjects
Drug Evaluation
Evaluation Studies as Topic
Humans
Immunotherapy
Interferon Type I - therapeutic use
Killer Cells, Natural - immunology
Neoplasms - immunology
Neoplasms - therapy
Statistics as Topic
Time Factors
Online AccessGet more information

Cover

More Information
Summary:In studying the effects of a treatment intervention on immunological parameters, we have found that three baseline values are a practical number to obtain on each patient. Three baseline values 1) increase the chances of detecting a statistically significant effect of the intervention, 2) provide an assessment of the daily variability of the assay and patients, and 3) enable the identification of individual patients who demonstrate significant changes associated with the intervention.
ISSN:0171-2985
DOI:10.1016/S0171-2985(84)80075-3