Formal total synthesis of camptothecin via ring-closing metathesis strategy

[Display omitted] A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the dihydropyridone...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 37; pp. 6879 - 6882
Main Authors Chavan, Subhash P., Pasupathy, K., Venkatraman, M.S., Kale, Ramesh R.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 06.09.2004
Elsevier
Subjects
Anticancer
Camptothecin
Chemistry
Chemistry, Organic
Physical Sciences
Pyridone
Ring-closing metathesis (RCM)
Science & Technology
Camptothecin
Anticancer
Pyridone
Ring-closing metathesis (RCM)
ring-closing metathesis (RCM)
camptothecin
pyridone
CHEMISTRY
PLANT ANTITUMOR AGENTS
TOPOISOMERASE-I
anticancer
CATALYSTS
ALKALOIDS
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Summary:[Display omitted] A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the dihydropyridone 3 .
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.07.101