In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (...

Full description

Saved in:
Bibliographic Details
Published inJournal of young pharmacists Vol. 9; no. 2; pp. 296 - 298
Main Authors Wahyuni, Fatma Sri, Hui, Lim Siang, Stanslas, Johnson, Lajis, Nordin Hj, D, Dachriyanus
Format Journal Article
LanguageEnglish
Published Bangalore InPharm 01.04.2017
Online AccessGet full text

Cover

More Information
Summary:Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.
ISSN:0975-1483
0975-1505
DOI:10.5530/jyp.2017.9.58