Novel and efficient synthesis of 1β-methylcarbapenems utilizing cyclization of hypervalent iodonium ylides

lβ-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.

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Bibliographic Details
Published inTetrahedron letters Vol. 36; no. 44; pp. 8043 - 8046
Main Authors Kume, Masaharu, Kubota, Tadatoshi, Iso, Yasuyoshi
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 30.10.1995
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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ISSN0040-4039
1873-3581
DOI10.1016/0040-4039(95)01703-K

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Summary:lβ-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)01703-K