Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in Vertebrates

Mechanosensitivity is a fundamental physiological capacity, which pertains to all life forms. Progress has been made with regard to understanding mechanosensitivity in bacteria, flies, and worms. In vertebrates, however, the molecular identity of mechanotransducers in somatic and neuronal cells has...

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Bibliographic Details
Published inCurrent topics in membranes Vol. 79; pp. 197 - 217
Main Authors Anderson, E O, Schneider, E R, Bagriantsev, S N
Format Journal Article
LanguageEnglish
Published United States 2017
Subjects
Animals
Humans
Ion Channels - metabolism
Mechanotransduction, Cellular
Merkel Cells - cytology
Proprioception
Skin Physiological Phenomena
Vertebrates - metabolism
Vertebrates - physiology
Dorsal root ganglia
Mechanoreception
Proprioception
Somatosensitivity
Mechanosensitivity
Mechanotransduction
Piezo2
Trigeminal ganglia
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Summary:Mechanosensitivity is a fundamental physiological capacity, which pertains to all life forms. Progress has been made with regard to understanding mechanosensitivity in bacteria, flies, and worms. In vertebrates, however, the molecular identity of mechanotransducers in somatic and neuronal cells has only started to appear. The Piezo family of mechanogated ion channels marks a pivotal milestone in understanding mechanosensitivity. Piezo1 and Piezo2 have now been shown to participate in a number of processes, ranging from arterial modeling to sensing muscle stretch. In this review, we focus on Piezo2 and its role in mediating mechanosensation and proprioception in vertebrates.
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ObjectType-Review-2
ISSN:1063-5823
DOI:10.1016/bs.ctm.2016.11.002