Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16

Using cDNA probes for the human uvomorulin (UVO) and rat chymotrypsinogen B (CTRB) genes, we have analyzed two overlapping interstitial deletions on human chromosome 16q by Southern blot analysis. One deletion, with breakpoints at 16q22.1 and 16q22.3, results in loss of the UVO locus. The second del...

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Bibliographic Details
Published inCytogenetics and cell genetics Vol. 50; no. 2-3; p. 145
Main Authors Natt, E, Magenis, R E, Zimmer, J, Mansouri, A, Scherer, G
Format Journal Article
LanguageEnglish
Published Switzerland 1989
Subjects
Blotting, Southern
Cadherins
Cells, Cultured
Child
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 16 - ultrastructure
Chymotrypsinogen - genetics
Female
Humans
Membrane Glycoproteins - genetics
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Summary:Using cDNA probes for the human uvomorulin (UVO) and rat chymotrypsinogen B (CTRB) genes, we have analyzed two overlapping interstitial deletions on human chromosome 16q by Southern blot analysis. One deletion, with breakpoints at 16q22.1 and 16q22.3, results in loss of the UVO locus. The second deletion, whose breakpoints are at 16q22.1 and 16q23.2, leads to loss of the CTRB locus. Therefore, UVO resides between both proximal deletion breakpoints within band 16q22.1, whereas CTRB is located between both distal breakpoints at 16q22.3 and 16q23.2.
ISSN:0301-0171
DOI:10.1159/000132745