Rat embryonic ectoderm as renal isograft
Experimental results obtained many years ago revealed that during gastrulation (with the primitive streak and the mesoderm formation as distinct features) the early rodent embryo undergoes essential changes in its response to extrinsic teratogens (Russell & Russell, 1954; Wilson, 1954; Å kreb, 1...
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Published in | Development (Cambridge) Vol. 94; no. 1; pp. 1 - 27 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
London
The Company of Biologists Limited
01.06.1986
Cambridge University Press |
Subjects | |
Online Access | Get full text |
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Summary: | Experimental results obtained many years ago revealed that during gastrulation (with the primitive streak and the mesoderm formation as distinct features) the early rodent embryo undergoes essential changes in its response to extrinsic teratogens (Russell & Russell, 1954; Wilson, 1954; Å kreb, 1961; Å kreb & BijeliÄ, 1962; Å kreb & Frank, 1963). It has also been shown that the ultrastructural, histochemical and biosynthetic features of the embryo are subject to substantial changes during this period (Solter, Damjanov & Å kreb, 1970, 1973; Dziadek & Adamson, 1978; Bode & Dziadek, 1979; Wartiovaara, Leivo & Vaheri, 1979; Jackson et al. 1981; Franke et al. 1982 a, b ). This suggests a restriction of developmental capacities (i.e. the loss of the capacity of regulation) in groups of embryonic cells at this developmental stage. According to the current concept, the initial cell population from which this restriction starts, resides within the embryonic ectoderm of the pregastrulation or preprimitive streak embryo (primitive or primary ectoderm). |
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ISSN: | 0950-1991 0022-0752 1477-9129 |
DOI: | 10.1242/dev.94.1.1 |