Rat embryonic ectoderm as renal isograft

• Published in: Development (Cambridge) Vol. 94; no. 1; pp. 1 - 27
• Main Authors: SVAJGER, A, LEVAK-SVAJGER, B, SKREB, N
• Format: Journal Article
• Language: English
• Published: London The Company of Biologists Limited 01.06.1986; Cambridge University Press
• Subjects: Animals; Biological and medical sciences; Cell Differentiation; Chick Embryo; Ectoderm - cytology; Ectoderm - transplantation; Embryology: invertebrates and vertebrates. Teratology; Experimental organogenesis; Fundamental and applied biological sciences. Psychology; Gastrula - cytology; Kidney - cytology; Kidney - growth & development; Mice; Morphogenesis; Organogenesis. Physiological fonctions; Rats; Teratoma - embryology; Teratoma - pathology; Terminology as Topic; Transplantation, Isogeneic; Cell culture; Renal capsule; Ectoderm; Embryo; Transplantation; Differenciation capacity
• ISSN: 0950-1991; 0022-0752; 1477-9129
• DOI: 10.1242/dev.94.1.1

Experimental results obtained many years ago revealed that during gastrulation (with the primitive streak and the mesoderm formation as distinct features) the early rodent embryo undergoes essential changes in its response to extrinsic teratogens (Russell & Russell, 1954; Wilson, 1954; Škreb, 1961; Škreb & Bijelić, 1962; Škreb & Frank, 1963). It has also been shown that the ultrastructural, histochemical and biosynthetic features of the embryo are subject to substantial changes during this period (Solter, Damjanov & Škreb, 1970, 1973; Dziadek & Adamson, 1978; Bode & Dziadek, 1979; Wartiovaara, Leivo & Vaheri, 1979; Jackson et al. 1981; Franke et al. 1982 a, b ). This suggests a restriction of developmental capacities (i.e. the loss of the capacity of regulation) in groups of embryonic cells at this developmental stage. According to the current concept, the initial cell population from which this restriction starts, resides within the embryonic ectoderm of the pregastrulation or preprimitive streak embryo (primitive or primary ectoderm).