Bioactive factors and biosynthetic materials in bone grafting

The ability to initiate bone repair with bioactive factors and delivery systems is contingent upon understanding and mimicking biochemical and cellular events that occur in response to autograft and allograft repair. This review develops the concept that osseous repair must be linked to a time-depen...

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Bibliographic Details
Published inClinics in plastic surgery Vol. 21; no. 3; p. 415
Main Authors Hollinger, J O, Seyfer, A E
Format Journal Article
LanguageEnglish
Published United States 01.07.1994
Subjects
Animals
Biocompatible Materials
Bone and Bones - metabolism
Bone and Bones - physiology
Bone and Bones - surgery
Bone Regeneration - physiology
Bone Transplantation - methods
Growth Substances - metabolism
Humans
Osseointegration - physiology
Prostheses and Implants
Sutures
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Summary:The ability to initiate bone repair with bioactive factors and delivery systems is contingent upon understanding and mimicking biochemical and cellular events that occur in response to autograft and allograft repair. This review develops the concept that osseous repair must be linked to a time-dependent sequence of structured events, the chronobiologic continuum of wound repair. Selected factors that have shown promise for promoting bone formation are discussed. The deployment of select factors by a biodegradable delivery system that fulfills physiologic requirements for osseous repair is explored.
ISSN:0094-1298
DOI:10.1016/S0094-1298(20)31018-X