Blood-brain barrier disruption in the treatment of brain tumors

Standard chemotherapy administered systemically has a limited efficacy in the treatment of brain tumors. One of the major obstacles in the treatment of brain neoplasias is the impediment to delivery across the intact blood-brain barrier (BBB). Many innovative approaches have been developed to circum...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 686; p. 447
Main Authors Blanchette, Marie, Fortin, David
Format Journal Article
LanguageEnglish
Published United States 2011
Subjects
Animals
Antineoplastic Agents - therapeutic use
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - physiology
Brain Neoplasms - diagnosis
Brain Neoplasms - drug therapy
Drug Delivery Systems
Evans Blue
Immunohistochemistry
Magnetic Resonance Imaging
Male
Permeability
Rats
Rats, Wistar
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Summary:Standard chemotherapy administered systemically has a limited efficacy in the treatment of brain tumors. One of the major obstacles in the treatment of brain neoplasias is the impediment to delivery across the intact blood-brain barrier (BBB). Many innovative approaches have been developed to circumvent this obstacle. One such strategy is BBB disruption (BBBD), which successfully increases the delivery of antineoplastic agents to the central nervous system (CNS). This chapter describes the application of the BBBD technique in rats. Different methods to evaluate and measure BBB permeability following hyperosmolar mannitol infusion including Evans blue staining, albumin immunohistochemistry, and dynamic magnetic resonance imaging are also described.
ISSN:1940-6029
DOI:10.1007/978-1-60761-938-3_23