Broadly applicable polysiloxane-based chiral stationary phase for high-performance liquid chromatography and supercritical fluid chromatography

A recently reported broad-spectrum chiral selector and two of its homologs were incorporated into polymethyl-hydrosiloxane and each of the polymers was immobilized on silica gel to afford chiral stationary phases (CSPs) useful for the separation of the enantiomers of a wide variety of compounds by H...

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Bibliographic Details
Published inJournal of Chromatography A Vol. 705; no. 2; pp. 185 - 194
Main Authors Terfloth, Gerald J., Pirkle, William H., Lynam, Kenneth G., Nicolas, Edgar C.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 30.06.1995
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Summary:A recently reported broad-spectrum chiral selector and two of its homologs were incorporated into polymethyl-hydrosiloxane and each of the polymers was immobilized on silica gel to afford chiral stationary phases (CSPs) useful for the separation of the enantiomers of a wide variety of compounds by HPLC and/or supercritical fluid chromatography (SFC). These CSPs are stable toward normal-phase, reversed-phase, and sub/supercritical fluid conditions and are not adversely affected by addition of carboxylic acids or amines as mobile-phase modifiers. These polymeric CSPs show higher efficiencies and shorter analysis times when used with sub/supercritical carbon dioxide then when used in the HPLC mode. Additionally, some separations are achievable using sub/supercritical carbon dioxide but not when the same column is used in the HPLC mode.
ISSN:0021-9673
DOI:10.1016/0021-9673(95)00246-J