Effect of Choline Alfoscerate on Cognitive Dysfunction After Mild Traumatic Brain Injury: A Single-Center Prospective Case-Control Study

• Published in: Korean journal of neurotrauma Vol. 21; no. 2; pp. 114 - 123
• Main Authors: Park, Mu Seung, Yang, Jin Seo, Kang, Suk-Hyung, Choi, Hyuk Jai, Jeon, Jin Pyeong, Cho, Yong-Jun
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Neurotraumatology Society 01.04.2025; 대한신경손상학회
• Subjects: Clinical; 신경외과학; Cognitive dysfunction; Mild traumatic brain injury; Choline alfoscerate
• ISSN: 2234-8999; 2288-2243
• DOI: 10.13004/kjnt.2025.21.e17

The purpose of this study was to determine the effect of choline alfoscerate on the recovery of cognitive function in patients with mild traumatic brain injury. Patients with mild traumatic brain injuries were included. The Korean version of the Mini-Mental State Examination (K-MMSE) was used to evaluate cognitive function. The K-MMSE was performed on the 7th day post-trauma. The patients were divided into the choline and control groups (15 subjects). The choline group was administered choline alfoscerate (400 mg) twice daily for 8 weeks. After 8 weeks, the K-MMSE was administered to both groups, and the results were compared with those before treatment. Thirty patients (15 each in the choline and control groups) were enrolled between November 2013 and March 2015. The mean ages were 64.2±12.1 and 63.7±16.8 years for the choline and control groups, respectively. The K-MMSE scores on the 7th day post-trauma were 21.7±6.2 and 25.1±4.3 for the choline and control groups, respectively. The K-MMSE scores at 9 weeks post-trauma were 24.1±5.1 and 25.7±4.4 for the choline and control groups, respectively. The change in cognitive function during the 8-weeks was 2.5±2.1 and 0.5±0.9 for the choline and control groups, respectively. The choline group showed greater cognitive improvement than the control group ( =0.004). Choline alfoscerate improves cognitive function in patients with mild traumatic brain injuries.