Macrophage (monocyte)-derived mucous secretagougue (MMS) is released into the fluid of the middle ear of patients with otitis media with effusion

Macrophage (monocyte)-derived secretagogue (MMS) is a low molecular weight peptide released by activated macrophages. This substance can enhance incorporation of carbohydrates into protein and result in the production of glycoproteins. It is believed that increased glycoproteins lead to the increase...

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Bibliographic Details
Published inOtolaryngology-head and neck surgery Vol. 103; no. 1; p. 1
Main Authors Bernstein, J M, Goswami, S, Marom, Z
Format Journal Article
LanguageEnglish
Published England 01.07.1990
Subjects
Adolescent
Cells, Cultured
Child
Child, Preschool
Ear, Middle - physiopathology
Glycoproteins - physiology
Glycoproteins - secretion
Humans
Infant
Middle Aged
Monocytes - secretion
Mucus - physiology
Otitis Media with Effusion - physiopathology
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Summary:Macrophage (monocyte)-derived secretagogue (MMS) is a low molecular weight peptide released by activated macrophages. This substance can enhance incorporation of carbohydrates into protein and result in the production of glycoproteins. It is believed that increased glycoproteins lead to the increased tenaciousness of mucoid effusions. Sixteen of 28 middle ear effusions demonstrated significant amounts of MMS. It is suggested that MMS is produced by activated macrophages in MEE and may lead to the development of glycoprotein by secretory epithelial cells. This substance may lead to the development of the mucoid effusion in otitis media with effusion in children.
ISSN:0194-5998
DOI:10.1177/019459989010300101