In vitro effect of fresh frozen plasma on the activated coagulation time in patients undergoing cardiopulmonary bypass

The in vitro effect of fresh frozen plasma (FFP) on the whole blood activated coagulation time (ACT) was examined in 18 patients undergoing cardiopulmonary bypass (CPB) during coronary artery bypass graft surgery. The addition of FFP to whole blood in vitro, after systemic heparinization, significan...

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Published inAnesthesia and analgesia Vol. 67; no. 1; pp. 57 - 60
Main Authors BARNETTE, R. E, SHUPAK, R. C, PONTIUS, J, KONETI RAO, A
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott 1988
Subjects
Adult
Aged
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antithrombin III - analysis
Biological and medical sciences
Blood Coagulation
Blood Transfusion
Cardiopulmonary Bypass
Coronary Artery Bypass
Drug Resistance
Female
Heparin - administration & dosage
Humans
In Vitro Techniques
Male
Medical sciences
Middle Aged
Plasma
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
Time Factors
Whole Blood Coagulation Time
Cardiopulmonary bypass
Human
Blood coagulation
Fresh blood
General anesthesia
Frozen product
Activated clotting time
Blood plasma
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Summary:The in vitro effect of fresh frozen plasma (FFP) on the whole blood activated coagulation time (ACT) was examined in 18 patients undergoing cardiopulmonary bypass (CPB) during coronary artery bypass graft surgery. The addition of FFP to whole blood in vitro, after systemic heparinization, significantly prolonged the ACT from 451 +/- 21 seconds (mean +/- SE) to 572 +/- 41 seconds (P less than 0.05). There was no significant correlation between the plasma antithrombin III activity and the prolongation in ACT after systemic heparinization, with or without addition of FFP. The addition of FFP to whole blood in three of the six patients who exhibited heparin resistance (ACT less than 400 seconds after administration of 350 unit/kg heparin) did not prolong the ACT to greater than 400 seconds. These observations suggest that infusion of FFP will further prolong the ACT after heparin administration in most patients including some with initial heparin resistance.
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ISSN:0003-2999
1526-7598
DOI:10.1213/00000539-198801000-00011