The Relationship between Leptin Concentration and Bone Metabolism in the Human Fetus
This study investigates the relationship between leptin and fetal bone metabolism by measuring fetal blood levels of leptin, carboxy-terminal pro-peptide of type I pro-collagen (PICP; a marker of bone formation) and cross-linked carboxy-terminal telopeptide of type I collagen (ICTP; a marker of bone...
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Published in | The journal of clinical endocrinology and metabolism Vol. 85; no. 5; pp. 1997 - 1999 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Endocrine Society
01.05.2000
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Online Access | Get full text |
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Summary: | This study investigates the relationship between leptin and fetal bone
metabolism by measuring fetal blood levels of leptin, carboxy-terminal
pro-peptide of type I pro-collagen (PICP; a marker of bone formation)
and cross-linked carboxy-terminal telopeptide of type I collagen (ICTP;
a marker of bone resorption). The median gestational age at the time of
sampling was 23 weeks (range, 18–35). There was a positive correlation
between leptin concentration and gestational age (r = 0.543,
P < 0.001) and a negative correlation between both
PICP and ICTP and gestational age (r = −0.592 and r =−
0.550, respectively, and P < 0.001 for both).
Also, there was a negative correlation between the concentrations of
leptin and both PICP (r = −0.260, P = 0.022)
and ICTP (r = −0.622, P < 0.001). Using
multiple regression analysis, fetal leptin concentration was positively
correlated to the gestational age (r = 0.240,
P = 0.042) and negatively correlated to ICTP
(r = −0.420, P = 0.001). The increase in
leptin concentration with gestational age is consistent with adipose
tissue development and the subsequent accumulation of fat mass. The
negative correlation between fetal leptin and ICTP suggests that leptin
may decrease bone resorption with the overall effect of increasing bone
mass. Therefore, leptin may play a role in fetal bone metabolism as
part of its effect on fetal growth and development. |
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ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jcem.85.5.6591 |