Regulated transcription of herpes simplex virus immediate-early genes in neuroblastoma cells

C1300 neuroblastoma cells are nonpermissive for infection with herpes simplex virus but can be rendered permissive by pretreatment with sodium butyrate. This increased permissivity which is specific for HSV is caused by increased transcription of the viral immediate-early genes following infection o...

Full description

Saved in:
Bibliographic Details
Published inVirology (New York, N.Y.) Vol. 171; no. 2; pp. 607 - 610
Main Authors Kemp, L.M., Latchman, D.S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1989
Subjects
Animals
Butyrates - pharmacology
Butyric Acid
Gene Expression Regulation - drug effects
Genes, Viral
In Vitro Techniques
Mice
Neuroblastoma
Neurons - microbiology
RNA, Viral - genetics
Simplexvirus - genetics
Time Factors
Transcription, Genetic
Tumor Cells, Cultured
Online AccessGet full text

Cover

More Information
Summary:C1300 neuroblastoma cells are nonpermissive for infection with herpes simplex virus but can be rendered permissive by pretreatment with sodium butyrate. This increased permissivity which is specific for HSV is caused by increased transcription of the viral immediate-early genes following infection of butyrate-treated cells and can be observed for at least 24 hr following withdrawal of butyrate. The use of C1300 cells as a model system for studying the regulation of immediate-early gene expression in neuronal cells in vitro and its possible relevance to the study of the processes regulating latent infection in vivo is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(89)90631-4