Synthesis and characterization of paclitaxel nanoparticles for drug delivery

Transformation of paclitaxel, an FDA (Food and Drug Administration) approved highly potent anticancer drug, to its nano dimensions was achieved using bioenhancers namely piperine and quercetin. After addition of bio enhancer, paclitaxel nanoparticles expressed better solubility and bioavailability i...

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Bibliographic Details
Published inMaterials today : proceedings Vol. 51; pp. 445 - 450
Main Authors Gade, Jaya V., Prashant Sharma, Prince, Jain, Bhawana, Rawat, Reena
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.01.2022
Subjects
Bioenhancers
Nanoparticles
Paclitaxel
Piperine
Quercetin
Nanoparticles
Bioenhancers
Piperine
Paclitaxel
Quercetin
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Summary:Transformation of paclitaxel, an FDA (Food and Drug Administration) approved highly potent anticancer drug, to its nano dimensions was achieved using bioenhancers namely piperine and quercetin. After addition of bio enhancer, paclitaxel nanoparticles expressed better solubility and bioavailability in comparison to free paclitaxel. The size, morphology, entrapment efficiency, diffusion pattern, cytotoxicity and pharmacokinetic behaviour were studied for the transformed drug. The shape and size of paclitaxel mixed with piperine and quercetin were characterized by transmission electron microscopy (TEM). The particle size was found between 95 nm and 155 nm having oval shape. The entrapment efficiency of particles was found to be increased with the addition of bioenhancers and the cytotoxicity of the particles was also found in acceptable range. The observations suggest the nano transformation of paclitaxel and addition of bioenhancers may enhance the efficacy of anticancer activity of paclitaxel.
ISSN:2214-7853
2214-7853
DOI:10.1016/j.matpr.2021.05.573