Chromium-51 Ethylenediaminetetraacetate for Estimation of Glomerular Filtration Rate

Renal clearances of inulin and chromium-51 ethylenediaminetetraacetate were compared in sheep. In 41 clearance periods from five animals the mean clearance ratio of the chelate to inulin was 0.95± 0.03 (S.D.). Part of the difference between the two sets of results may have been due to binding of the...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 152; no. 3725; pp. 1076 - 1077
Main Authors Stacy, B. D., Thorburn, G. D.
Format Journal Article
LanguageEnglish
Published American Association for the Advancement of Science 20.05.1966
Subjects
Animals
Blood proteins
Chelates
Glomerular filtration rate
Isotopes
Isotopic labeling
Kidneys
Renal clearance
Renal function
Sheep
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Summary:Renal clearances of inulin and chromium-51 ethylenediaminetetraacetate were compared in sheep. In 41 clearance periods from five animals the mean clearance ratio of the chelate to inulin was 0.95± 0.03 (S.D.). Part of the difference between the two sets of results may have been due to binding of the metal chelate by plasma protein since 1.5 to 2 percent of chromium-51 ethylenediaminetetraacetate in plasma could not be removed by dialysis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.152.3725.1076