Fabrication of rapid-biodegradable nano-vectors for endosomal-triggered drug delivery

• Published in: Journal of drug delivery science and technology Vol. 55; p. 101450
• Main Authors: Peng, Si-Yuan, Zou, Mei-Zhen, Zhang, Cai-Xia, Ma, Jun-Bin, Zeng, Xuan, Xiao, Wang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2020
• Subjects: Biodegradable; Hydrophobic interaction; Organosilica nanoparticles; pH-response; Hydrophobic interaction; pH-response; Biodegradable; Organosilica nanoparticles
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2019.101450

Nanoparticles that respond to specific stimulus to achieve controlled release of anticancer drug have been vastly investigated for years. In this study, we focused on the development of low-residue organosilica nanoparticles (OSNPs), which were obtained by introducing biodegradable group into the monomer. DOX was loaded via the hydrophobic interaction between benzene and the drug. The drug release results revealed that the DOX could be fast liberated from the nanoparticles under acidic condition, indicating the high pH-response of the nanoparticles and the fine protection of anticancer drug. And the results of the cell viability showed promising efficiency in cancer therapy. Importantly, supported with the TEM figures and the degradation assessment, the nanoparticles were proved to be disintegrated into low molecular weight residues, rapidly and completely, predicting the possible few remains in vivo. We synthesized biodegradable organosilica nanoparticles for endosomal-triggered anti-cancer drug delivery. The nanoparticles were highly sensitive to the acidic environment due to the acidity-labile imine bond, on which the fast release of the drug and good cancer treatment could be achieved. More importantly, the degradation assessment confirmed that the nanoparticles could be disintegrated into low molecular weight residues, thus would possibly reduce the residues in vivo as well as the potential metabolic troubles. [Display omitted]