Differential Effects of Prostaglandins on Lordosis Behavior in Female Guinea Pigs and Rats
The facilitatory and inhibitory effects of prostaglandins PGE 2 and PGF 2α on lordosis behavior were compared in guinea pigs and rats. In the first part of experiment 1, PGE 2 or PGF 2α (500 µg) failed to facilitate significantly lordosis behavior in ovariectomized, estradiol benzoate (EB)-primed...
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Published in | Biology of reproduction Vol. 20; no. 4; pp. 853 - 861 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Society for the Study of Reproduction
01.05.1979
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Subjects | |
Online Access | Get full text |
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Summary: | The facilitatory and inhibitory effects of prostaglandins PGE 2 and PGF 2α on lordosis behavior
were compared in guinea pigs and rats. In the first part of experiment 1, PGE 2 or PGF 2α (500 µg)
failed to facilitate significantly lordosis behavior in ovariectomized, estradiol benzoate (EB)-primed
guinea pigs. However, in the second part of experiment 1, in guinea pigs treated with EB followed
44 h later by progesterone (P), PGE 2 and PGF 2α (500 µg) significantly inhibited lordosis responses
when given at the same time as P, 5 h after P (at the onset of heat) or 8 h after P (at the time of
maximal lordosis responding). Doses of 20 µg or 100 µg PGE 2 or PGF 2α also inhibited lordosis
responding when given 5 h after P to EB-primed guinea pigs. Oxytocin treatment (100 mU or
500 mU) given 5 h after P to EB-primed guinea pigs had no effect on subsequent lordosis responding. In experiment 2, PGE 2 (100 µg) significantly facilitated lordosis in EB-primed rats but, in
contrast to guinea pigs, 500 µg PGE 2 or PGF 2α had no inhibitory effect on lordosis behavior when
given 4 or 8 h after P treatment to EB-primed rats. Inhibitory effects of prostaglandins on lordosis
behavior in guinea pigs and facilitatory effects of prostaglandins on lordosis behavior in rats may be
indicative of differential neurochemical mechanisms for the regulation of lordosis behavior in
guinea pigs and rats. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-3363 1529-7268 |
DOI: | 10.1095/biolreprod20.4.853 |