Correlations between cell-cycle perturbations and survival levels after exposure to adriamycin for two Chinese hamster cell lines

The cell-cycle perturbation and cell inactivation after adriamycin (ADR) exposure were measured in two Chinese hamster cell lines differing in ADR sensitivity. Based on DNA distribution analysis, it was found that the rate of G 1 fraction depletion following low-dose ADR treatment was related to the...

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Published inEuropean journal of cancer & clinical oncology Vol. 19; no. 4; pp. 547 - 551
Main Authors Tokita, N., Jett, J.H., Raju, M.R., Belli, J.A.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1983
Subjects
Animals
Cell Cycle - drug effects
Cell Line
Cell Survival - drug effects
Cells, Cultured
Cricetinae
Cricetulus
DNA - analysis
Dose-Response Relationship, Drug
Doxorubicin - pharmacology
Interphase - drug effects
Time Factors
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Summary:The cell-cycle perturbation and cell inactivation after adriamycin (ADR) exposure were measured in two Chinese hamster cell lines differing in ADR sensitivity. Based on DNA distribution analysis, it was found that the rate of G 1 fraction depletion following low-dose ADR treatment was related to the level of cell inactivation. The results indicate that gross cellular sensitivity to ADR can be predicted rapidly by this approach.
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ISSN:0277-5379
DOI:10.1016/0277-5379(83)90120-7