Neuropeptides, nerve growth factor, and mucosal immunity

Since the discovery more than 20 years ago that IgA in its secretory form of dimeric IgA covalently linked with the glycoprotein, secretory component (SC), the predominant immunoglobulin in external secretions, the emphasis has been on this molecule as a prime mediator of mucosal immunity. While the...

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Published inBrain, behavior, and immunity Vol. 2; no. 4; pp. 311 - 317
Main Authors Pezzati, Paola, Mueller, Aimee, Bienenstock, John, Stanisz, Andrzej M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.12.1988
Subjects
Animals
Immune System - metabolism
Nerve Growth Factors - physiology
Neuropeptides - physiology
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Summary:Since the discovery more than 20 years ago that IgA in its secretory form of dimeric IgA covalently linked with the glycoprotein, secretory component (SC), the predominant immunoglobulin in external secretions, the emphasis has been on this molecule as a prime mediator of mucosal immunity. While there is no doubt that IgA is an important effector molecule, there is increasing evidence that often it may be only a marker of an effective mucosal response and that other mechanisms are involved in inducing mucosal resistance.
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ISSN:0889-1591
1090-2139
DOI:10.1016/0889-1591(88)90033-5