Factors Associated with Treatment Failure and Radiosurgery-Related Edema in WHO Grade 1 and 2 Meningioma Patients Receiving Gamma Knife Radiosurgery

• Published in: World neurosurgery Vol. 130; pp. e558 - e565
• Main Authors: O'Connor, Kyle P, Algan, Ozer, Vesely, Sara K, Palejwala, Ali H, Briggs, Robert G, Conner, Andrew K, Cornwell, Benjamin O, Andrews, Bethany, Sughrue, Michael E, Glenn, Chad A
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019
• Subjects: Adolescent; Adult; Aged; Brain Edema - etiology; Disease Progression; Female; Humans; Male; Meningeal Neoplasms - pathology; Meningeal Neoplasms - radiotherapy; Meningioma - pathology; Meningioma - radiotherapy; Middle Aged; Radiosurgery - adverse effects; Retrospective Studies; Risk Factors; Treatment Failure; Young Adult; Edema; Predictive factors; Meningioma; Local failure; Gamma knife
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2019.06.152

Before the advent of radiosurgery, neurosurgical treatment of meningiomas typically involved gross total resection of the mass whenever surgery was deemed possible. Over the past 4 decades, though, Gamma Knife radiosurgery (GKRS) has proved to be an effective, minimally invasive means to control the growth of these tumors. However, the variables associated with treatment failure (regrowth or clinical progression) after GKRS and GKRS-related complications, such as cerebral edema, are less well understood. We retrospectively collected data between 2009 and 2018 for patients who underwent GKRS for meningiomas. After data collection, we performed univariate and multivariable modeling of the factors that predict treatment failure and cerebral edema after GKRS. Hazard ratios (HR) and P values were determined for these variables. Fifty-two patients were included our analysis. The majority of patients were female (38/52,73%), and nearly all patients presented with a suspected or confirmed World Health Organization grade 1 meningioma (48/52, 92%). The median tumor volume was 3.49 cc (range, 0.22-20.11 cc). Evidence of meningioma progression after treatment developed in 5 patients (10%), with a median time to continued tumor growth of 5.9 months (range, 2.7-18.3 months). In multivariable analysis, patients in whom treatment failed were more likely to be male (HR = 8.42, P = 0.045) and to present with larger tumor volumes (HR = 1.27, P = 0.011). In addition, 5 patients (10%) experienced treatment-related cerebral edema. On univariate analysis, patients who experienced cerebral edema were more likely present with larger tumors (HR = 1.16, P = 0.028). Increasing meningioma size and male gender predispose to meningioma progression after treatment with GKRS. Increasing tumor size also predicts the development of postradiosurgery cerebral edema.