Signalling and autophagy regulation in health, aging and disease

It has become clear in recent years that autophagy not only serves to produce amino acids for ongoing protein synthesis and to produce substrates for energy production when cells become starved but autophagy is also able to eliminate defective cell structures and for this reason the process may be i...

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Bibliographic Details
Published inMolecular aspects of medicine Vol. 27; no. 5; pp. 411 - 425
Main Authors Meijer, Alfred J., Codogno, Patrice
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2006
Elsevier
Subjects
Aging
Aging - physiology
Amino acids
AMPK
Animals
ATP
Autophagy
Cancer
Cellular Biology
Diabetes
Disease
Health
Humans
Insulin
Life Sciences
mTOR
Neurodegenerative diseases
Phosphatidylinositol phospholipids
Signal Transduction
S6
PTEN
Amino acids
PtdInsP
Phosphatidylinositol phospholipids
PI3K
Rheb
IRS1,2
mTOR
PDK1
UVRAG
Neurodegenerative diseases
TSC
PKB
(m)TOR
IR
S6K
MAPK
Insulin
IP3
Atg
PIP
ROS
AMPK
AICAR
4E-BP1
Diabetes
ATP
PtdIns(3,4,5)P 3
Cancer
ERK
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Summary:It has become clear in recent years that autophagy not only serves to produce amino acids for ongoing protein synthesis and to produce substrates for energy production when cells become starved but autophagy is also able to eliminate defective cell structures and for this reason the process may be implicated in several diseased states. Autophagy is controlled by complex signalling pathways, including that used by insulin. In these pathways, phosphatidylinositol 3-kinases and the protein kinase mTOR play important roles.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2006.08.002