THE PERIODATE OXIDATION OF AMINO ACIDS WITH REFERENCE TO STUDIES ON GLYCOPROTEINS

1. All alpha-amino acids are oxidized by periodate, but at different rates. 2. The rates of oxidation of individual alpha-amino acids vary with pH. In general, oxidation proceeds more rapidly at alkaline pH. 3. Serine, threonine, cysteine, cystine, methionine, proline, hydroxyproline, tryptophan, ty...

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Published inBiochemical journal Vol. 94; no. 1; pp. 17 - 24
Main Authors CLAMP, J R, HOUGH, L
Format Journal Article
LanguageEnglish
Published England 01.01.1965
Subjects
Amino Acids
Cysteine
Cystine
Glycoproteins
Histidine
Hydrogen-Ion Concentration
Hydroxyproline
Indoles
Isoleucine
Leucine
Methionine
Old Medline
Oxidation-Reduction
Periodic Acid
Phenylalanine
Proline
Pyrroles
Serine
Threonine
Tryptophan
Tyrosine
TRYPTOPHAN
HYDROXYPROLINE
OXIDATION-REDUCTION
EXPERIMENTAL LAB STUDY
GLYCOPROTEINS
CYSTEINE
HYDROGEN-ION CONCENTRATION
PERIODIC ACIDS
PYRROLES
INDOLES
CYSTINE
SERINE
HISTIDINE
TYROSINE
AMINO ACIDS
PROLINE
THREONINE
METHIONINE
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Summary:1. All alpha-amino acids are oxidized by periodate, but at different rates. 2. The rates of oxidation of individual alpha-amino acids vary with pH. In general, oxidation proceeds more rapidly at alkaline pH. 3. Serine, threonine, cysteine, cystine, methionine, proline, hydroxyproline, tryptophan, tyrosine and histidine are rapidly and extensively oxidized by periodate. 4. Cysteine, cystine, methionine, tryptophan, tyrosine and histidine are oxidized by periodate when they are substituted in the carboxyl and amino groups, as in a polypeptide chain.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Present address: Department of Medicine, Bristol Royal Infirmary, Bristol, 2.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj0940017