UAG readthrough is not increased in vivo by Moloney murine leukemia virus infection

Expression of the pol gene of the murine leukemia viruses subject to translational control at the UAG termination codon of the upstream gene gag. Previous experiments have suggested that: i) Moloney murine leukemia virus infection induces a tRNA Glniii) in an in vitro system using the tobacco mosaic...

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Bibliographic Details
Published inBiochimie Vol. 73; no. 10; pp. 1291 - 1293
Main Authors Berteaux, V., Rousset, J.P., Cassan, M.
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.10.1991
Subjects
3T3 Cells
Animals
Base Sequence
Cell Transformation, Viral
Codon - genetics
DNA, Viral - genetics
Genes, gag
Genes, pol
luciferase
Mice
Molecular Sequence Data
Moloney murine leukemia virus - genetics
Protein Biosynthesis
readthrough
RNA, Transfer, Gln - genetics
translation
virus infection
readthrough
Mo-MuLV
nt
translation
luciferase
TMV
virus infection
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Summary:Expression of the pol gene of the murine leukemia viruses subject to translational control at the UAG termination codon of the upstream gene gag. Previous experiments have suggested that: i) Moloney murine leukemia virus infection induces a tRNA Glniii) in an in vitro system using the tobacco mosaic virus as template, this tRNA is able to increase readthrough at the UAG codon [1]. Here we demonstrate that, in vivo, Moloney murine leukemia virus infection does not increase translational readthrough at either the tobacco mosaic virus or the Moloney murine leukemia virus UAG stop codons.
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ISSN:0300-9084
1638-6183
DOI:10.1016/0300-9084(91)90091-E