Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review

• Published in: Korean journal of orthodontics (2012) Vol. 54; no. 5; pp. 284 - 302
• Main Authors: Andrade, Ana Luiza Cabral de Ávila, Pinto, Yasmin Dias de Almeida, Maia, Bernardo Emerenciano Barros, Corrêa, Joice Dias, Miranda, Diogo de Azevedo, Manzi, Flávio Ricardo, Lima, Izabella Lucas de Abreu
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Association of Orthodontists 25.09.2024; 대한치과교정학회
• Subjects: Original; 치의학; Root resorption; Genetic research; Genetic polymorphism
• ISSN: 2234-7518; 2005-372X
• DOI: 10.4041/kjod24.030

External apical root resorption (EARR) is characterized by permanent loss of dental structure at the root apex. This study aimed to systematically review gene polymorphisms associated with EARR in orthodontic patients. Electronic database searches were performed across several databases. This systematic review included 21 studies. Outcome measures were based on tooth dimensions observed on radiographs obtained before and after treatment. Polymorphisms in the following genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis: purinergic-receptor-P2X, ligand-gated ion channel 7 ( ), caspase-1/interleukin-converting enzyme ( / ), caspase-5 ( ), IL-1beta ( ), IL-1alpha ( ), interleukin-1 receptor antagonist gene ( ), tissue non-specific alkaline phosphatase ( ), tumor necrosis factor-alpha ( ), tumor necrosis factor receptor superfamily gene member 11a ( ), secreted phosphoprotein 1 ( ), tumor necrosis factor receptor superfamily gene member 11b ( ), interleukin 17A ( ), interleukin 6 ( ), receptor activator of nuclear factor-kappa B ( ), osteoprotegerin ( ), stromal antigen 2 ( ), vitamin D receptor ( ), cytochrome P450 family 24 subfamily A member 1 ( ), cytochrome P450 family 27 subfamily B ( ), group-specific component ( ), and interleukin-1 receptor-associated kinases 1 ( ). Almost all studies suggested that IL1 gene is associated with EARR. Additionally, may be an important factor contributing to the etiopathogenesis of EARR. , , , , , , , , , / and have been identified in isolated studies. Further observational studies are needed to better explain the association between these genes and EARR.