Sumoylation of PDX-1 Regulates the Rat Insulin 2 Gene Transcription

• Published in: Applied Mechanics and Materials Vol. 556-562; pp. 253 - 256
• Main Authors: Jian, Ruo Lei, Wang, Feng Po, Wang, Nan, Mao, Li Bin, Zhang, Tong Cun
• Format: Journal Article
• Language: English
• Published: Zurich Trans Tech Publications Ltd 01.05.2014
• Subjects: Sumoylation; SUMO-1; Insulin; PDX-1

Insulin is essential for maintaining glucose homeostasis and is synthesized and secreted almost exclusively from pancreatic β-cells in the islets of Langerhans. The analysis of rat insulin2 promoter sequences indicates that it has pancreatic and duodenal homeobox factor-1 (PDX-1) binding site. In ma...