Mitochondrial adaptation in steatotic mice
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and...
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| Published in | Mitochondrion Vol. 40; pp. 1 - 12 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
01.05.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals. |
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| AbstractList | Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals. |
| Author | Zischka, Hans Walheim, Ellen Artmann, Renate Simmons, Alisha Schnurr, Max Schmitt, Sabine Mayr, Doris Wimmer, Ralf Denk, Gerald Eberhagen, Carola Gerbes, Alexander L Wottke, Lena Schulz, Sabine Hauck, Stefanie M von Toerne, Christine Einer, Claudia Jastroch, Martin Borchard, Sabine Vollmar, Angelika M Hohenester, Simon Popper, Bastian Leitzinger, Christin Gosmann, Christian Rust, Christian |
| Author_xml | – sequence: 1 givenname: Claudia surname: Einer fullname: Einer, Claudia organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 2 givenname: Simon surname: Hohenester fullname: Hohenester, Simon organization: Department of Medicine II, Liver Center Munich, University Hospital LMU Munich, 81377 Munich, Germany – sequence: 3 givenname: Ralf surname: Wimmer fullname: Wimmer, Ralf organization: Department of Medicine II, Liver Center Munich, University Hospital LMU Munich, 81377 Munich, Germany – sequence: 4 givenname: Lena surname: Wottke fullname: Wottke, Lena organization: Department of Medicine II, Liver Center Munich, University Hospital LMU Munich, 81377 Munich, Germany – sequence: 5 givenname: Renate surname: Artmann fullname: Artmann, Renate organization: Department of Medicine II, Liver Center Munich, University Hospital LMU Munich, 81377 Munich, Germany – sequence: 6 givenname: Sabine surname: Schulz fullname: Schulz, Sabine organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 7 givenname: Christian surname: Gosmann fullname: Gosmann, Christian organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 8 givenname: Alisha surname: Simmons fullname: Simmons, Alisha organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 9 givenname: Christin surname: Leitzinger fullname: Leitzinger, Christin organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 10 givenname: Carola surname: Eberhagen fullname: Eberhagen, Carola organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 11 givenname: Sabine surname: Borchard fullname: Borchard, Sabine organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 12 givenname: Sabine surname: Schmitt fullname: Schmitt, Sabine organization: Institute of Toxicology and Environmental Hygiene, Technical University of Munich, 80802 Munich, Germany – sequence: 13 givenname: Stefanie M surname: Hauck fullname: Hauck, Stefanie M organization: Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 14 givenname: Christine surname: von Toerne fullname: von Toerne, Christine organization: Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 15 givenname: Martin surname: Jastroch fullname: Jastroch, Martin organization: Institute of Diabetes and Obesity, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 16 givenname: Ellen surname: Walheim fullname: Walheim, Ellen organization: Institute of Diabetes and Obesity, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany – sequence: 17 givenname: Christian surname: Rust fullname: Rust, Christian organization: Department of Medicine I, Krankenhaus Barmherzige Brüder, 80639 Munich, Germany – sequence: 18 givenname: Alexander L surname: Gerbes fullname: Gerbes, Alexander L organization: Department of Medicine II, Liver Center Munich, University Hospital LMU Munich, 81377 Munich, Germany – sequence: 19 givenname: Bastian surname: Popper fullname: Popper, Bastian organization: Biomedical Center, Department of Anatomy and Cell biology, LMU Munich, 82152, Planegg-Martinsried, Germany – sequence: 20 givenname: Doris surname: Mayr fullname: Mayr, Doris organization: Department of Pathology, LMU Munich, 80337 Munich, Germany – sequence: 21 givenname: Max surname: Schnurr fullname: Schnurr, Max organization: Division of Clinical Pharmacology & Center for Integrated Protein Science Munich (CIPSM), Klinikum der Universität München, 80337 Munich, Germany – sequence: 22 givenname: Angelika M surname: Vollmar fullname: Vollmar, Angelika M organization: Department of Pharmacy, Center for Drug Research, Pharmaceutical Biology, LMU Munich, 81377 Munich, Germany – sequence: 23 givenname: Gerald surname: Denk fullname: Denk, Gerald organization: Department of Medicine II, Liver Center Munich, University Hospital LMU Munich, 81377 Munich, Germany – sequence: 24 givenname: Hans surname: Zischka fullname: Zischka, Hans email: zischka@helmholtz-muenchen.de organization: Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University of Munich, 80802 Munich, Germany. Electronic address: zischka@helmholtz-muenchen.de |
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| Keywords | Mitochondria NAFLD Steatosis Western diet |
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