Soluble interleukin-2 receptor in cancer

Levels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of alpha-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to...

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Bibliographic Details
Published inFrontiers in bioscience Vol. 9; no. 1-3; pp. 3085 - 3090
Main Author Murakami, Saburo
Format Journal Article
LanguageEnglish
Published United States 01.09.2004
Subjects
Biomarkers, Tumor
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Interleukin-2 - metabolism
Lymphocytes, Tumor-Infiltrating - metabolism
Male
Neoplasms - metabolism
Receptors, Interleukin-2 - blood
Receptors, Interleukin-2 - physiology
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Summary:Levels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of alpha-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to its specific IL-2R membrane. In most malignant diseases, elevated levels of serum sIL-2R are found, compare to normal control. Serum sIL-2R is a useful parameter for evaluating the disease stage and monitoring the disease progression during the post-treatment follow-up, though it is not an organ-specific parameter.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1093-9946
1093-4715
DOI:10.2741/1461