Junctions in DNA: underexplored targets for therapeutic intervention

• Published in: Bioorganic & medicinal chemistry Vol. 69; p. 116897
• Main Authors: Ivens, Eleanor, Cominetti, Marco M.D., Searcey, Mark
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2022
• Subjects: Four-way junction; Holliday Junction; Three-way junction; Four-way junction; Three-way junction; Holliday Junction

[Display omitted] DNA has been a key target for cancer therapy, with a range of compounds able to bind and either impair its processing or induce damage. Targeting DNA with small molecules in a truly sequence specific way, to impair gene specific processes, remains out of reach. The ability of DNA t...