Junctions in DNA: underexplored targets for therapeutic intervention

[Display omitted] DNA has been a key target for cancer therapy, with a range of compounds able to bind and either impair its processing or induce damage. Targeting DNA with small molecules in a truly sequence specific way, to impair gene specific processes, remains out of reach. The ability of DNA t...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 69; p. 116897
Main Authors Ivens, Eleanor, Cominetti, Marco M.D., Searcey, Mark
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.2022
Subjects
Four-way junction
Holliday Junction
Three-way junction
Four-way junction
Three-way junction
Holliday Junction
Online AccessGet full text

Cover

More Information
Summary:[Display omitted] DNA has been a key target for cancer therapy, with a range of compounds able to bind and either impair its processing or induce damage. Targeting DNA with small molecules in a truly sequence specific way, to impair gene specific processes, remains out of reach. The ability of DNA to assume different structures from the classical double helix allows access to more specific ligand binding modes and, potentially, to new avenues of treatment. In this review, we illustrate the small molecules that have been reported to bind to three- and four-way junctions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0968-0896
1464-3391
1464-3391
DOI:10.1016/j.bmc.2022.116897