Reversing the mitochondrial hex that bewitches NLRP3

Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik ).

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Bibliographic Details
Published inScience immunology Vol. 8; no. 84; p. eadh2967
Main Authors Mellacheruvu, Manasa, Lawrence, Grace M E P, Emming, Stefan, Schroder, Kate
Format Journal Article
LanguageEnglish
Published United States 23.06.2023
Subjects
Inflammasomes - metabolism
Mitochondria
Mitochondrial Membranes - metabolism
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Signal Transduction
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Summary:Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik ).
ISSN:2470-9468
DOI:10.1126/sciimmunol.adh2967