Therapeutic deep eutectic system of capric acid and menthol: Characterization and pharmaceutical application

• Published in: Journal of drug delivery science and technology Vol. 53; p. 101159
• Main Authors: Al-Akayleh, Faisal, Mohammed Ali, Hiba Hani, Ghareeb, Mowafaq M., Al-Remawi, Mayyas
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2019
• Subjects: Fluconazole; Mometazone furoate; Solubilization; Therapeutic deep eutectic solvent; Therapeutic deep eutectic solvent; Fluconazole; Solubilization; Mometazone furoate
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2019.101159

The work outlined herein describes an evaluation of a new green solvent working as a drug solubility enhancer made up of a eutectic system comprising mixtures of capric acid and menthol. Fluconazole and mometasone furoate were tested as two common model drugs. The system suitability in enhancing drug solubility was carried out at three different capric acid: menthol mass ratios of 4:1, 1:1, and 1:4. Characterizing the phase forming mechanics involved in drug-related solubility was illustrated in this work by investigating the surface tension, contact angle, and viscosity of the mixtures at the same aforementioned capric acid: menthol ratios. Moreover, system compatibility with the two model drugs was given considerable attention using DSC and FTIR analysis. The system exhibited a decrease in surface tension (30–60%) and viscosity (30–70%) from initial values compared to common strong solvents in addition to a high wettability as indicated by low values of contact angles (<24 ⁰). Results further confirmed the effectiveness of the eutectic mixture in enhancing drug solubility. A cream preparation comprising the two drugs and their eutectic solvent constituents was evaluated for any acute skin irritation/erosion effect on Albino rabbits. [Display omitted]