Sodium homeostasis and signalling: The core and the hub of astrocyte function

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na ions in astrocytes. These changes constitute the substrate for Na signalling and are fundamental for astrocytic excitability. Astrocytic Na signals are generated by Na influx throug...

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Bibliographic Details
Published inCell calcium (Edinburgh) Vol. 117; p. 102817
Main Authors Rose, Christine R, Verkhratsky, Alexej
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2024
Subjects
Astrocytes - metabolism
Homeostasis - physiology
Membrane Transport Proteins
Signal Transduction - physiology
Sodium - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Stroke
Na(+) signalling
Na(+)/K(+) pump
SLC transporters
Astrocyte
pH regulation
Hepatic encephalopathy
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Summary:Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na ions in astrocytes. These changes constitute the substrate for Na signalling and are fundamental for astrocytic excitability. Astrocytic Na signals are generated by Na influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na transients is mediated mainly by the plasmalemmal Na /K ATPase. Astrocytic Na signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.
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ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2023.102817