Carbon nanotubes in drug delivery: Focus on anticancer therapies

Despite significant advancements in cancer therapy, many therapeutic limitations such as off-target side effects, drug or gene instability, and multi-drug resistance (MDR), pose a major challenge for achieving an effective cure. The application of nanotechnology in biomedical research has allowed re...

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Bibliographic Details
Published inJournal of drug delivery science and technology Vol. 59; p. 101892
Main Authors Ravi Kiran, A.V.V.V., Kusuma Kumari, G., Krishnamurthy, Praveen T.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.10.2020
Subjects
Biomolecule
Cancer
Carbon nanotubes
Drug delivery
RNAi
Targeted therapy
Biomolecule
Carbon nanotubes
RNAi
Drug delivery
Targeted therapy
Cancer
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Summary:Despite significant advancements in cancer therapy, many therapeutic limitations such as off-target side effects, drug or gene instability, and multi-drug resistance (MDR), pose a major challenge for achieving an effective cure. The application of nanotechnology in biomedical research has allowed researchers to address some of these problems. Among various nano-delivery systems, carbon nanotubes (CNTs) have gained a lot of importance due to their large surface area, biocompatibility, and potentials to deliver large cargos of drugs and biomolecules. In the recent era, novel functionalized CNTs have been developed to address some of the shortcomings of conventional CNTs and utilize them as a better nano-delivery system. The present review focusses on various types of CNTs, their modifications, applications, and challenges in cancer therapy. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2020.101892