Ononin Alleviates Sublesional Bone Loss and Inflammation Following Spinal Cord Injury in Rats by Regulating Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathway

Inhibition of bone loss is one of the ways to alleviate motor dysfunction caused by spinal cord injury, a lifelong and lifechanging injury. Isoflavone from legumes that include ononin, Calycosin-7-O-β-Glucoside, and others have been shown to have potential for the treatment of orthopedic diseases. W...

Full description

Saved in:
Bibliographic Details
Published inCurrent topics in nutraceuticals research Vol. 20; no. 4; pp. 648 - 653
Main Authors Yang, Xiaokai, Liu, Shuai, Wang, Zhengqiang
Format Journal Article
LanguageEnglish
Published New Century Health Publishers, LLC 01.11.2022
Subjects
Adenosine
Adenosine triphosphate
Bones
Calcium-binding proteins
Density
Glycogen
Inflammation
Isoflavones
Mitogens
Phosphatases
Polyvinylidene fluoride
Protein kinases
Spinal cord injuries
Surface active agents
Synthesis
China
Online AccessGet full text
ISSN1540-7535
DOI10.37290/ctnr2641-452X.20:648-653

Cover

More Information
Summary:Inhibition of bone loss is one of the ways to alleviate motor dysfunction caused by spinal cord injury, a lifelong and lifechanging injury. Isoflavone from legumes that include ononin, Calycosin-7-O-β-Glucoside, and others have been shown to have potential for the treatment of orthopedic diseases. While there are potentials for ononin to improve the motor function of spinal cord injury, studies on the subject are lacking. To this end, we examined the ameliorative role of ononin in an animal model of spinal cord injury. Our results show the ononin reduced inflammatory response, decreased femoral bone loss, and promoted osteoblast formation in rats with spinal cord injury through promotion of adenosine 5′′-monophosphate-activated protein kinase signaling pathway.
ISSN:1540-7535
DOI:10.37290/ctnr2641-452X.20:648-653