The in vivo and in vitro action of 4-amino-5-imidazolecarboxamide in trypanosomatid flagellates

• Published in: Molecular and biochemical parasitology Vol. 3; no. 5; pp. 265 - 269
• Main Authors: Kidder, George W., Nolan, Linda L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.1981
• Subjects: 4-Amino-5-imidazolecarboxamide; Aminoimidazole Carboxamide - analogs & derivatives; Aminoimidazole Carboxamide - pharmacology; Animals; Growth inhibitor; Guanine Deaminase - antagonists & inhibitors; Guanine deaminase inhibitor; Imidazoles - pharmacology; Leishmania - drug effects; Leishmania - enzymology; Leishmania - growth & development; Leishmania braziliensis; Leishmania donovani; Leishmania mexicana; Leishmania tarentolae; Ribonucleosides - pharmacology; Trypanosoma cruzi - drug effects; Trypanosoma cruzi - enzymology; Trypanosoma cruzi - growth & development; Trypanosomatids; AICA-RP; Growth inhibitor; Trypanosomatids; Guanine deaminase inhibitor; AICA-R; PRPP; FFH 4; 4-Amino-5-imidazolecarboxamide; AICA
• ISSN: 0166-6851; 1872-9428
• DOI: 10.1016/0166-6851(81)90001-3

4-Amino-5-imidazolecarboxamide, but not its riboside or ribotide, is inhibitory to the growth of promastigotes of Leishmania donovani, L. braziliensis, L. tarentolae, and L. mexicana, eventually causing cell lysis. Conversely, it is not inhibitory to the growth of epimastigotes of Trypanosoma cruzi. This substituted imidazole proved to be an excellent inhibitor of guanine deaminase from all of the trypanosomatids used in this study, with K i values in the μM range.