PVC membrane Sensor Immobilized with Clopidogrel-Tetraiodo Bismuthate for the Potentiometric Determination of Clopidogrel from Pharmaceutical Formulations

This paper describes the fabrication of potentiometric PVC membrane for clopidogrel bisulphate and its successful utilization in the determination clopidogrel from clopilet tablet. Effect of PVC membrane matrix were studied and optimized membrane composition which ensued a Nernstian slope of 58.83±0...

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Bibliographic Details
Published inMaterials today : proceedings Vol. 5; no. 9; pp. 17812 - 17819
Main Authors Santhy, A., Saraswathyamma, B., Uma Sankar, P., Vidya, R., Rejithamol, R.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2018
Subjects
clopidogrel
clopidogrel-tetraidobismuthate
Potentiometry
PVC membrane sensor
clopidogrel
Potentiometry
clopidogrel-tetraidobismuthate
PVC membrane sensor
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Summary:This paper describes the fabrication of potentiometric PVC membrane for clopidogrel bisulphate and its successful utilization in the determination clopidogrel from clopilet tablet. Effect of PVC membrane matrix were studied and optimized membrane composition which ensued a Nernstian slope of 58.83±0.340mV/decade was found to be PVC 32%, ion association 3%,NaTBP 2% and DBP 63 % respectively. Sensor revealed a fast response time of 3s in the concentration range 1×10-2 -1×10-6 M with a lower detection limit of 9.12 ×10-7M. Working pH range and response time was found to be 2.0 - 4.5 and 5s respectively. Comparative studies on the various parameters that depend on the potential response of the present sensor with that of the literature reports were also included
ISSN:2214-7853
2214-7853
DOI:10.1016/j.matpr.2018.06.106